Point of Interest Mid-Infrared Spectroscopy for Inline Pharmaceutical Packaging Quality Control
نویسندگان
چکیده
Good manufacturing practice for medicinal products is laid down in several guidelines and Directives of the European Commission. Those regulations imply, among other aspects, that manufacturers have to ensure final are fit their intended use do not place patients at risk due inadequate safety, quality or efficacy. For case pharmaceutical blisters, attainment this objective leads often resourcing qualified personnel visual verification blister pack content. The need inline content blisters asks therefore sensors provide fast, non-contact accurate chemical information each individual Here we report on a quantum cascade laser (QCL)-based blister-verification sensor. principle substance identification by means backscattering mid-infrared spectroscopy. light source palm-size wavelength-tunable QCL with ~1 kHz tuning speed. uses machine vision obtain required position fast spatial scanning facilitated 2-axis galvanometer scanner. Diffuse reflectance spectra acquired location classification conducted instantaneously. Different classifier approaches evaluated discussed including learning standard cross-correlation Fourier-transform-infrared (FTIR) data. Altogether, sensor capable 12-pill ~0.3 s, whereas time essentially related desired accuracy, but spectral resolution, which fixed. Using classification, 100% accuracy demonstrated 13 different medication-types (i.e., nature), only 97.4% achieved FTIR used pills all similar size, shape color, so inspection barely possible.
منابع مشابه
Application of mid-infrared spectroscopy in the quality control of traditional Chinese medicines.
Chinese herbal medicines are often referred to as Chinese materia medica (CMM). Composite formulae containing mixtures of CMM are prescribed for treatment and prevention of diseases in the practice of traditional Chinese medicine (TCM). Some of the well-known CMM formulae (Fufang in Chinese) are manufactured and marketed as proprietary Chinese medicines (PCM). Quality assessment and assurance o...
متن کاملNear-infrared spectroscopy applications in pharmaceutical analysis.
Near-infrared (NIR) spectroscopy is a fast and non-destructive analytical technique that offers many advantages for a broad range of industrial applications. In this work, we reviewed recent developments in the pharmaceutical domain where it can be applied from raw material identification to final product release. The characteristics of NIR allow the technique to be implemented as a process ana...
متن کاملSoil Classification Via Mid-infrared Spectroscopy
The need for rapid and inexpensive techniques for soil characterization has led to the investigation of modern technologies, and in particular those based on reflectance spectroscopy. While near-infrared has been traditionally used, midinfrared in the 400-4000 cm-1 range is becoming increasingly common due to the specificity of the absorbance bands in this spectral range. The present work discu...
متن کاملMid-Infrared Imaging Spectroscopy in Ophiuchus
The dust emission spectrum between 5 and 16 m has been measured at the northern edge of the dense cloud in Ophiuchus at a position where the radiation field intensity is estimated to be 10-20 times the mean Solar neighborhoodvalue. The spectrum shows the well known emission bands at 6.2, 7.7, 8.6, 11.3 and 12.7 m. ISO allows to detect the emission features for a radiation field intensity two or...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: IEEE Sensors Journal
سال: 2023
ISSN: ['1558-1748', '1530-437X']
DOI: https://doi.org/10.1109/jsen.2023.3281972